منابع مشابه
High throughput drug profiling
High throughput screening has significantly contributed to advances in drug discovery. The great increase in the number of samples screened has been accompanied by increases in costs and in the data required for the investigated compounds. High throughput profiling addresses the issues of compound selectivity and specificity. It combines conventional screening with data mining technologies to g...
متن کاملHigh-throughput expression profiling techniques.
Great optimism exists that correlating genomics with function will lead to a better understanding of the detailed workings of the nervous system. The nearly complete sequencing of the genomes of several eukaryotic species and the invention of high-throughput expression profiling techniques now provide the means to rapidly investigate the molecular underpinnings of phenotypic change with reasona...
متن کاملHigh throughput drug pro ling
High throughput screening has signi cantly contributed to advances in drug discovery. The great increase in the number of samples screened has been accompanied by increases in costs and in the data required for the investigated compounds. High throughput pro ling addresses the issues of compound selectivity and speci city. It combines conventional screening with data mining technologies to g...
متن کاملHigh-throughput phosphotyrosine profiling using SH2 domains.
Protein tyrosine phosphorylation controls many aspects of signaling in multicellular organisms. One of the major consequences of tyrosine phosphorylation is the creation of binding sites for proteins containing Src homology 2 (SH2) domains. To profile the global tyrosine phosphorylation state of the cell, we have developed proteomic binding assays encompassing nearly the full complement of huma...
متن کاملAdipogenic Transcriptome Profiling Using High Throughput Technologies
The recent technological innovations in the area of functional genomics, gene expression/transcriptomic profiling can provide new insights to understand the molecular basis of adipogenesis. The focus of this review is to highlight the recent advances in our understanding of the complex interplay of gene expression events and the regulatory mechanisms of adipogenesis in mouse cell lines, humans ...
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ژورنال
عنوان ژورنال: JALA: Journal of the Association for Laboratory Automation
سال: 2000
ISSN: 1535-5535
DOI: 10.1016/s1535-5535-04-00085-1